20200901 Regular City Council Meeting - Packet (4) September 1,2020
Item 12
Staff Presentation
Coronavirus vaccines in large -scale trials
• Moderns
• AstraZeneca/Oxford University
• Gamaleya Research Institute "Sputnik"
• Sinovac
• Wuhan Institute of Biological Products
• Jonhson&Johnson
• Pfizer (Sept)
• Novavax (Oct-Nov) Bop=
For these first two trials, Core NIAID sites have been selected
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CORONAVIRUS PREVENTION NETWORK
AWW
COVID -19
Prevention Network
AZ Ph III I roVPN 3002
At
www. coronaviruspreventionnetwork . org
Phase III double-blind placebo-controlled trial of
AstraZeneca/Oxford Univ. recombinant adenovirus vector vaccine
expressing SARS-Co-V2 spike protein : ChAdOx1 nCoV- 1 9
• Replication-incompetent e N=30,000
chimp adenovirus vector • Randomized 2: 1 vaccine:placebo
• Also used for other vaccines • Two shots 4 weeks apart
• Phase 1 data show high rate e 7 in-person visits over 2 years
of neutralizing antibodies
with 1 dose • Also includes outpatient acute illness
evaluations (at Keck Hospital)
• Target 35% age 65 and older
• Focus on other high-risk groups
• Healthcare
• Industrial
-' - • Group settings COVID-19
Prevention Network
SCI-venilag Treatment Day 1 and Day 9 and Follow-tile X"isits
8tudv Ilav -14 to 1 1 8 15 29 36 43 57 90 180 360 7,10
Vaccine visits
t t t t t t t t In-person visits
Population
Adults �! 18 vears
of e Two do s e s x 101 vp (nominal_- 1. 1010 xF each; Lei
Healthy or have r
medical Iv-stable E -
chronic diseases
L Saline Placebo
• At ilncreasedrisk TNvo doses. INM (n = 10 000)
for 8A1 - oV-
aoquisitionand Monitor for COO D-19
VID-1 9
Tolerability
• Chills, fever, headache, joint
pain-tenderness , malaise, Severity
o Mild M Mm�.re M s�r.
Pain Redness SxMling aMeires
myalgia , nausea all more T
common w/ChAdOx1 nCoV- 1 9
• May last 1 -2 days _ k_ With par cetamol
_ - - - — _JL
• 2ndvaccination better tolerated Without
• Modest reduction in reactions
with acetominophen
Folegatti, Lancet 2020
Community engagement efforts
• CENTRAL • LOCAL
• Key faith leaders • Satellite site at Vernon
• Underserved/increased risk racial • Smithfield Foods
populations • Supermarket workers
• Geriatric population (assisted living) • Healthcare workers
• Occupational engagement (industries • Assisted living residents
and unions) • Social Media
• Pre-existing health conditions • Mass media outreach
• Celebrity champions
• Social media • Also being done at UCLA, Harbor-
• www.coronaviruspreventionnetwork.orb UCLA in Torrance
• www.preventcovid.or�
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COV I O-19 English
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�Que es un estudio clinico? Que puedes anticipar cuando eres uoluntario
Conocesobre[as diferentes etapas de[as estudios cLinicos y accede a Antes,durante ydespues de la prueba,estamos aqui para corrtestar
Line lista de estudios de vacunas y anticuerpos_ cualquier pregunta quetengas.
www.p reve ntcovi